Ascending Growth is Associated with Offspring Adiposity in Pregnancies Complicated with Obesity or Gestational Diabetes

Abstract Context Early growth is associated with childhood adiposity, but the influence of lifestyle remains unknown. Objective This work aimed to investigate association profiles from high-risk pregnancies adiposity at age 5 years, taking into account and several antenatal/postnatal exposures. Methods prospective cohort study included 609 children born during Finnish Gestational Diabetes Prevention Study (RADIEL), recruiting women body mass index (BMI) greater than or equal 30 and/or prior gestational diabetes mellitus (GDM) (2008-2013). Altogether 332 attended 5-year follow-up (2014-2017). Main outcome measures based on ponderal (PI = weight/height3), investigated using latent class mixed models. Adiposity was assessed anthropometrics composition (InBody720). Results We identified 3 profiles: ascending (n 82), intermediate 351), descending 149). Children had a higher fat percentage, ISO-BMI, waist circumference (P < .05) years. Ascending (β 4.09; CI, 1.60-6.58) 2.27; 0.50-4.03) were even after adjustment for age, sex, diet, physical activity, education, prepregnancy BMI. Similar associations existed ISO-BMI. After adjusting BMI (odds ratio [OR] 1.06; 1.01-1.12), primiparity (OR 3.07; 1.68-5.62), cesarean delivery 2.23; 1.18-4.21), intervention 2.56; 1.44-4.57). However, meeting goals exclusive breastfeeding months more lower odds growth. Conclusion Accelerated early in 5-year-old pregnancies, when adjusted lifestyle. Reducing deliveries promoting may be beneficial postnatal